PERSONALISED MEDICINE FOR BETTER HEALTH
About
Plexision develops cellular biomarkers for personalized diagnosis and drug development in solid organ transplantation and immunological disorders. We also pioneer in R&D projects centered on integrating biomarker targets in all phases of drug development, from preclinical to post-marketing. Plexision’s technology can be adapted to
- Assess disease risk for several immunological disorders.
- Predict the success of a drug for a specific patient.
- Develop dosing recommendations for new immunological drugs.
Our state-of-the-art laboratory is CLIA-certified and located in Pittsburgh, PA.
Contact
- +1 (855) 753-9474
- info@plexision.com
- 4424 Penn Ave., #202, Pittsburgh, PA 15224 USA
Mitogen Simulation
Mitogen stimulation
- Mitogens are non-specific stimulants of immune cells.
- Mitogen stimulation leads to immune cell activation and is used as a measure of general immune function. Common mitogens include phytohemagglutinin (PHA), phorbol-myristic-acid-calcium ionophore (PMA), pokeweed mitogen, and others.
- Some mitogens have more pronounced effects on some immune cells than others. For example, T-cells are strongly activated by PMA, while B-cells are strongly activated by pokeweed mitogens.
- Mitogen-stimulated immune responses serve as a positive control reaction in tests to measure antiviral immune cell function.
- Healthy immune cells respond to stimulation with mitogens.
- However, immune cells that respond to mitogens may not respond to other antigens.
- Early during viral infections, immune cells fail to respond to the virus but may continue to respond to mitogens.
- During immune deficiency, immune cells may fail to respond to viral antigens and mitogens.
- Most individuals are exposed to common viruses during their lifetimes.
- Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) are two such common viruses.
- The PlexCMV and PlexEBV assay measure T-cell immune responses to the CMV and EBV viruses.
- Both tests also measure T-cell immune cell response to mitogens, simultaneously.
- Selective loss of T-cell response to either virus is more common during infection with the corresponding virus.
- Global loss of T-cell response to common viruses and mitogens is more often seen with immune deficiency.
- To order tests or clarify questions, please reach us via email info@plexision.com or call us at +1 (855) 753-9474.
Early during viral infections, immune cells fail to respond to the virus, but may continue to respond to mitogens. Mitogen-stimulated immune responses serve as a positive control reaction in tests to measure antiviral immune cell function.